Andisheh Ghashghaie,
Tehran University of Medical Sciences, Iran
Title: Cord Blood Banking for Transplantation and Regenerative Medicine
Biography
Biography: Andisheh Ghashghaie,
Abstract
Collection and banking of umbilical cord blood (UCBs) can provide unlimited source of ethnically diverse donors. The main limitation factor for use of (UCBs) as a source of hematopoietic progenitors for transplantation is cell dose. The engraftment outcome of UCB transplantation is highly dependent on nucleated cell number of unites. It would be useful to predict CB cell content using information of donor-related variables before cell processing.
Banked unrelated donor UCBs has improved access to hematopoietic stem cell transplantation for patients without a suitably matched donor. In a resource-limited environment, ensuring that the public inventory is enriched with high-quality (CBUs) addressing the needs of a diverse group of patients is a priority. Identification of donor characteristics correlating with higher CBU quality could guide operational strategies to increase the yield of banked high-quality CBUs.
In contrast family-directed CB collection and storage which requires different procedures in order to obtain high-quality products. This approach is clinically indicated and validated in families where the mother is pregnant and has an existing child or has a known risk of having a child affected by a disease which can be cured by allogeneic HSCT. It would be useful to predict CB cell content using information of donor-related variables before processing.
In this study, CBs were obtained from 3297 single-birth term deliveries in 3 hospitals affiliated to Tehran University of medical sciences from January 1998 to June 2016. Up to August 2016, 67 units have been used in transplantation for patients with malignant and non-malignant disorders. The attempt has been made to find factors which have significant effects on quality of CB units, including CB volume, TNCs, and CD34+ cell counts.